Preliminary normative variation of auditory P300 parameters in adult individuals

Background and Aim: Auditory P300 is an event-related potential. Cognitive factors like attention are involved in the generation of P300. It seems that normative variation of P300 is necessary for clinical purposes. Thus, the current study was designed to establish preliminary normative variation of P300 amplitude and latency at Fz and Cz sites in adults. Methods: This cross-sectional study was performed on 20 right-handed volunteers aged 18 to 33 years. P300 was recorded monaurally with two channels at Fz and Cz placements. Two tone bursts of 1000Hz and 2000Hz were used as frequent and target stimuli, respectively. Results: The mean values of P300 amplitude and latency at Cz were 7.43±2.61 μv and 325.19±21.34 ms in the right ear and 7.38±2.73μv and 320.29±21.56 ms in the left ear, respectively. At Fz, the mean values of P300 amplitude and latency were 5.34±1.74 μv and 330.09±25.58 ms in the right ear and 5.67±2.30 μv and 329.52±29.25 ms in the left ear, respectively. The differences between the ears at Cz and Fz were not statistically significant (p˃0.05). The mean value of amplitude of P300 was significantly greater at Cz than Fz (p=0.001) although the difference in latency was not statistically significant between Cz and Fz (p˃0.05). Conclusion: Amplitude of P300 was greater at Cz than Fz although latency was not different. Based on these findings, amplitude and latency values can be probably used for clinical purposes to assess auditory disorders.